BDBM50549723 CHEMBL4755291

SMILES [H][C@@]12CN(CCN1[C@H](C)CN(C2)c1ccc(C#N)c2nc([2H])ccc12)c1ncc(cc1C)N1CC2(CC(N)C2)C1

InChI Key InChIKey=CMEOTYMBSBSSBJ-WHRKIXHSSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50549723   

TargetToll-like receptor 7(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50549723(CHEMBL4755291)
Affinity DataIC50: 3nMAssay Description:Inhibition of human TLR7 expressed in HEK-Blue cells assessed as inhibition of R848-induced NF-kappaB and AP-1 activation measured after 20 hrs by qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetToll-like receptor 8(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50549723(CHEMBL4755291)
Affinity DataIC50: 4nMAssay Description:Inhibition of human TLR8 expressed in HEK-Blue cells assessed as inhibition of R848-induced NF-kappaB and AP-1 activation measured after 20 hrs by qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetToll-like receptor 9(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50549723(CHEMBL4755291)
Affinity DataIC50: 81nMAssay Description:Inhibition of human TLR9 expressed in HEK-Blue cells assessed as inhibition of ODN2006-induced NF-kappaB and AP-1 activation measured after 20 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed