BDBM50549724 CHEMBL4799678

SMILES [H][C@@]12CN(CCN1[C@H](C)CN(C2)c1ccc(C#N)c2ncccc12)c1cncc2CNCCc12

InChI Key InChIKey=RPHHNWILYSFFFK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50549724   

TargetToll-like receptor 9(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50549724(CHEMBL4799678)
Affinity DataIC50: 50nMAssay Description:Inhibition of human TLR9 expressed in HEK-Blue cells assessed as inhibition of ODN2006-induced NF-kappaB and AP-1 activation measured after 20 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetToll-like receptor 8(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50549724(CHEMBL4799678)
Affinity DataIC50: 1nMAssay Description:Inhibition of human TLR8 expressed in HEK-Blue cells assessed as inhibition of R848-induced NF-kappaB and AP-1 activation measured after 20 hrs by qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50549724(CHEMBL4799678)
Affinity DataIC50: 4nMAssay Description:Inhibition of human TLR7 expressed in HEK-Blue cells assessed as inhibition of R848-induced NF-kappaB and AP-1 activation measured after 20 hrs by qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed