BDBM50549726 CHEMBL4747784

SMILES [H][C@@]12CN(CCc3ccc(nc3)N3C[C@@H](N)[C@@H](F)C3)CCN1[C@H](C)CN(C2)c1ccc(C#N)c2ncccc12

InChI Key InChIKey=NGJZLHHIJBJNNG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50549726   

TargetToll-like receptor 8(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50549726(CHEMBL4747784)
Affinity DataIC50: 4nMAssay Description:Inhibition of human TLR8 expressed in HEK-Blue cells assessed as inhibition of R848-induced NF-kappaB and AP-1 activation measured after 20 hrs by qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50549726(CHEMBL4747784)
Affinity DataIC50: 6nMAssay Description:Inhibition of human TLR7 expressed in HEK-Blue cells assessed as inhibition of R848-induced NF-kappaB and AP-1 activation measured after 20 hrs by qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetToll-like receptor 9(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50549726(CHEMBL4747784)
Affinity DataIC50: 47nMAssay Description:Inhibition of human TLR9 expressed in HEK-Blue cells assessed as inhibition of ODN2006-induced NF-kappaB and AP-1 activation measured after 20 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed