BDBM50550252 CHEMBL4779054

SMILES CNC(=O)c1ccc(cn1)N1CCN([C@H](C)C1)c1cccc(n1)C(=O)NC1C2CC3CC1CC(O)(C3)C2

InChI Key

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50550252   

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Sk Chemicals

Curated by ChEMBL
LigandPNGBDBM50550252(CHEMBL4779054)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells using cortisone in presence of NADPH regenerating-system incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Sk Chemicals

Curated by ChEMBL
LigandPNGBDBM50550252(CHEMBL4779054)
Affinity DataIC50: 700nMAssay Description:Inhibition of CYP2C19 in pooled human liver microsomes using mephenytoin as substrate in presence of NADPH incubated for 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Sk Chemicals

Curated by ChEMBL
LigandPNGBDBM50550252(CHEMBL4779054)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in pooled human liver microsomes using diclofenac as substrate in presence of NADPH incubated for 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sk Chemicals

Curated by ChEMBL
LigandPNGBDBM50550252(CHEMBL4779054)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in pooled human liver microsomes using midazolam as substrate in presence of NADPH incubated for 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Sk Chemicals

Curated by ChEMBL
LigandPNGBDBM50550252(CHEMBL4779054)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in pooled human liver microsomes using phenacetin as substrate in presence of NADPH incubated for 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Sk Chemicals

Curated by ChEMBL
LigandPNGBDBM50550252(CHEMBL4779054)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in pooled human liver microsomes using dextromethorphan as substrate in presence of NADPH incubated for 10 mins by LC-MS/MS anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed