BDBM50551582 CHEMBL279301::E-4-Hydroxytamoxifen

SMILES CC\C(=C(\c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1)c1ccccc1

InChI Key InChIKey=TXUZVZSFRXZGTL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50551582   

TargetEstrogen receptor beta(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50551582(CHEMBL279301 | E-4-Hydroxytamoxifen)
Affinity DataIC50: 0.990nMAssay Description:Antagonist activity at ERbeta (unknown origin) expressed in human U2OS cells assessed as inhibition of E2-induced transactivation measured after 21 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50551582(CHEMBL279301 | E-4-Hydroxytamoxifen)
Affinity DataIC50: 1.70nMAssay Description:Displacement of fluorescent-labelled E2 from recombinant human GST-tagged ERbeta by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50551582(CHEMBL279301 | E-4-Hydroxytamoxifen)
Affinity DataIC50: 2.20nMAssay Description:Displacement of fluorescent-labelled E2 from recombinant human GST-tagged ERalpha by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50551582(CHEMBL279301 | E-4-Hydroxytamoxifen)
Affinity DataIC50: 2.30nMAssay Description:Antagonist activity at ERalpha (unknown origin) expressed in human U2OS cells assessed as inhibition of E2-induced transactivation measured after 21 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed