BDBM50552362 CHEMBL4764418

SMILES Cc1ccc(C)c(Nc2c(Cl)c(C)nc3ccc(cc23)-c2cnc(nc2)C(C)(C)O)c1

InChI Key InChIKey=PZADHIGHKUYCQX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50552362   

TargetTumor necrosis factor(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552362(CHEMBL4764418)
Affinity DataIC50: 51nMAssay Description:Displacement of fluorescent labeled probe from human recombinant His-tagged TNFalpha (77 to 233 residues) expressed in Escherichia coli preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552362(CHEMBL4764418)
Affinity DataIC50: 196nMAssay Description:Inhibition of exogenous human TNFalpha in HEK-Blue-CD40L cells assessed as reduction in TNF-alpha-induced NFkappaB activation incubated for 18 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552362(CHEMBL4764418)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of recombinant CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552362(CHEMBL4764418)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of recombinant CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed