BDBM50552378 CHEMBL4793073

SMILES C[C@@H](Nc1c(Cl)cnc2ccc(cc12)-c1cnc(nc1)C(C)(C)O)c1cc(ccc1F)N1CCCC1

InChI Key InChIKey=QTPFGQAQERVHJG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50552378   

TargetTumor necrosis factor(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552378(CHEMBL4793073)
Affinity DataIC50: 94nMAssay Description:Displacement of fluorescent labeled probe from human recombinant His-tagged TNFalpha (77 to 233 residues) expressed in Escherichia coli preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552378(CHEMBL4793073)
Affinity DataIC50: 331nMAssay Description:Inhibition of exogenous human TNFalpha in HEK-Blue-CD40L cells assessed as reduction in TNF-alpha-induced NFkappaB activation incubated for 18 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed