BDBM50552452 CHEMBL4747992

SMILES NC(=O)c1sc(nc1OCCCC1CCN(Cc2ccc(F)cc2)CC1)-c1ccnc(NC(=O)C2CC2)c1

InChI Key InChIKey=LQLBWZJHRARWDB-UHFFFAOYSA-N

Data  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50552452   

TargetGlycogen synthase kinase-3 beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552452(CHEMBL4747992)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged GSK3beta H350L mutant expressed in baculovirus infected Sf21 cells using prephosphorylated pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552452(CHEMBL4747992)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of DYRK1A (unknown origin) by ATP competitive based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552452(CHEMBL4747992)
Affinity DataIC50: 12nMAssay Description:Inhibition of GSK3alpha (unknown origin) by ATP competitive based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552452(CHEMBL4747992)
Affinity DataIC50: 16nMAssay Description:Inhibition of GSK3beta (unknown origin) by ATP competitive based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552452(CHEMBL4747992)
Affinity DataIC50: 38nMAssay Description:Inhibition of DYRK1B (unknown origin) by ATP competitive based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552452(CHEMBL4747992)
Affinity DataIC50: 108nMAssay Description:Inhibition of CDK9 (unknown origin) by ATP competitive based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552452(CHEMBL4747992)
Affinity DataIC50: 300nMAssay Description:Inhibition of CDK4 (unknown origin) by ATP competitive based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 6(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552452(CHEMBL4747992)
Affinity DataIC50: 300nMAssay Description:Inhibition of CDK6 (unknown origin) by ATP competitive based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552452(CHEMBL4747992)
Affinity DataIC50: 300nMAssay Description:Inhibition of CDK1 (unknown origin) by ATP competitive based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552452(CHEMBL4747992)
Affinity DataIC50: 300nMAssay Description:Inhibition of CDK2 (unknown origin) by ATP competitive based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552452(CHEMBL4747992)
Affinity DataIC50: 300nMAssay Description:Inhibition of JNK3 (unknown origin) by ATP competitive based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552452(CHEMBL4747992)
Affinity DataIC50: 300nMAssay Description:Inhibition of JNK2 (unknown origin) by ATP competitive based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552452(CHEMBL4747992)
Affinity DataIC50: 300nMAssay Description:Inhibition of p38MAPK beta (unknown origin) by ATP competitive based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552452(CHEMBL4747992)
Affinity DataIC50: 300nMAssay Description:Inhibition of p38MAPK alpha (unknown origin) by ATP competitive based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 13(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552452(CHEMBL4747992)
Affinity DataIC50: 300nMAssay Description:Inhibition of p38MAPK delta (unknown origin) by ATP competitive based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 12(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552452(CHEMBL4747992)
Affinity DataIC50: 300nMAssay Description:Inhibition of p38MAPK gamma (unknown origin) by ATP competitive based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552452(CHEMBL4747992)
Affinity DataIC50: 300nMAssay Description:Inhibition of ERK2 (unknown origin) by ATP competitive based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552452(CHEMBL4747992)
Affinity DataIC50: 300nMAssay Description:Inhibition of ERK1 (unknown origin) by ATP competitive based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552452(CHEMBL4747992)
Affinity DataIC50: 300nMAssay Description:Inhibition of CDK7 (unknown origin) by ATP competitive based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552452(CHEMBL4747992)
Affinity DataIC50: 310nMAssay Description:Inhibition of human recombinant AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate incubated for 10 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetCholinesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552452(CHEMBL4747992)
Affinity DataIC50: 3.41E+3nMAssay Description:Inhibition of human BChE using butyrylthiocholineiodide as substrate incubated for 10 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed