BDBM50552462 CHEMBL4759253

SMILES NC(=O)c1sc(nc1OCCC1CCN(Cc2ccccc2F)CC1)-c1ccnc(NC(=O)C2CC2)c1

InChI Key InChIKey=GTDYZHRXBKZMOG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50552462   

TargetGlycogen synthase kinase-3 beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552462(CHEMBL4759253)
Affinity DataIC50: 261nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged GSK3beta H350L mutant expressed in baculovirus infected Sf21 cells using prephosphorylated pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552462(CHEMBL4759253)
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of human recombinant AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate incubated for 10 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetCholinesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50552462(CHEMBL4759253)
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of human BChE using butyrylthiocholineiodide as substrate incubated for 10 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed