BDBM50552734 CHEMBL4793625

SMILES CCn1nc(C)cc1C(=O)Nc1nc2cc(cc(OC)c2n1CCCCNC(=O)OC(C)(C)C)C(N)=O

InChI Key InChIKey=GKBNCHFXERWSCQ-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50552734   

TargetStimulator of interferon genes protein(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50552734(CHEMBL4793625)
Affinity DataEC50:  794nMAssay Description:Agonist activity at full length human STING expressed in HEK293T cotransfected with pISRE-luc and cGAS incubated for 24 hrs by steady-glo luciferase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetStimulator of interferon genes protein(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50552734(CHEMBL4793625)
Affinity DataEC50:  804nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed