BDBM50553815 CHEMBL4794701

SMILES COc1ccc(cc1)-n1nnc2cnc(N[C@H]3CC[C@@H](CC3)C(N)=O)nc12

InChI Key InChIKey=JDUQEHFYOAZGKI-UHFFFAOYSA-N

Data  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50553815   

TargetMitogen-activated protein kinase 6(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50553815(CHEMBL4794701)
Affinity DataKd:  980nMAssay Description:Binding affinity to wild-type human partial length ERK3 (M1 to P413 residues) expressed in bacterial expression system by kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 6(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50553815(CHEMBL4794701)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to recombinant wild-type ERK3 (9 to 327 residues) (unknown origin) expressed in Sf21 insect cells by microscale thermophoresis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 6(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50553815(CHEMBL4794701)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity to recombinant wild-type ERK3 (9 to 327 residues) (unknown origin) expressed in Escherichia coli by microscale thermophoresis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 6(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50553815(CHEMBL4794701)
Affinity DataKd:  1.50E+3nMAssay Description:Binding affinity to LPP-dephosphorylated recombinant wild-type ERK3 (9 to 327 residues) (unknown origin) expressed in Escherichia coli by microscale ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed