BDBM50554099 CHEMBL4763513

SMILES CCn1nc(cc1Nc1nc(cs1)-c1ccc(c(OC)n1)-n1cnc(C)c1)C(F)(F)F

InChI Key InChIKey=UNFVPHNQVGXPKU-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50554099   

TargetPresenilin-1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554099(CHEMBL4763513)
Affinity DataIC50: 58nMAssay Description:Modulation of gamma secretase in human SH-SY5Y cells overexpressing wild type APP751 assessed as inhibition of amyloid beta (35 to 42 residues) forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554099(CHEMBL4763513)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of recombinant CYP3A4 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554099(CHEMBL4763513)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of recombinant CYP1A2 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554099(CHEMBL4763513)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of recombinant CYP2C19 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554099(CHEMBL4763513)
Affinity DataIC50: 1.89E+4nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554099(CHEMBL4763513)
Affinity DataIC50: 4.70E+4nMAssay Description:Inhibition of recombinant CYP2C9 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50554099(CHEMBL4763513)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant CYP2D6 (unknown origin) by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed