BDBM50555290 CHEMBL4747997::US11306078, Example 4.005

SMILES CN(C)C(=O)[C@H]1CN(CC[C@@H]1NC(=O)c1cc(on1)-c1ccc(F)cc1F)C1CCCCC1

InChI Key InChIKey=WTQZMARGZPHBHA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50555290   

TargetAtypical chemokine receptor 3(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555290(CHEMBL4747997 | US11306078, Example 4.005)
Affinity DataIC50: 7.40nMAssay Description:Antagonist activity at CXCR7 (unknown origin) expressed in CHO-K1 cells co-expressing beta-arrestin assessed as reduction in compound-1 induced respo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555290(CHEMBL4747997 | US11306078, Example 4.005)
Affinity DataIC50: 7.40nMAssay Description:Antagonist activity at CXCR7 (unknown origin) expressed in CHO-K1 cells co-expressing beta-arrestin assessed as reduction in compound-1 induced respo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555290(CHEMBL4747997 | US11306078, Example 4.005)
Affinity DataIC50: 66nMAssay Description:Antagonist activity at CXCR7 (unknown origin) expressed in human U2OS cells co-expressing beta-arrestin assessed as reduction in CXCL12-alpha induced...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555290(CHEMBL4747997 | US11306078, Example 4.005)
Affinity DataIC50: 66nMAssay Description:Antagonist activity at CXCR7 (unknown origin) expressed in human U2OS cells co-expressing beta-arrestin assessed as reduction in CXCL12-alpha induced...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555290(CHEMBL4747997 | US11306078, Example 4.005)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells at -40 mV holding potential by Q-patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555290(CHEMBL4747997 | US11306078, Example 4.005)
Affinity DataIC50: 388nMAssay Description:Tango CXCR7-bla U2OS cells are detached from culture dishes with 0.05% trypsin-EDTA and collected in growing medium (McCoy's 5A 90% (v/v), dialyz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2022
Entry Details
Go to US Patent