BDBM50555322 CHEMBL4784443::US11306078, Example 4.012

SMILES Fc1ccc(-c2cc(no2)C(=O)N[C@H]2CCN(C[C@@H]2C(=O)NCc2ccccc2)C2CCCCC2)c(F)c1

InChI Key InChIKey=FVQJXTBUZRFLEB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50555322   

TargetAtypical chemokine receptor 3(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555322(CHEMBL4784443 | US11306078, Example 4.012)
Affinity DataIC50: 36nMAssay Description:Antagonist activity at CXCR7 (unknown origin) expressed in human U2OS cells co-expressing beta-arrestin assessed as reduction in CXCL12-alpha induced...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555322(CHEMBL4784443 | US11306078, Example 4.012)
Affinity DataIC50: 36nMAssay Description:Antagonist activity at CXCR7 (unknown origin) expressed in human U2OS cells co-expressing beta-arrestin assessed as reduction in CXCL12-alpha induced...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555322(CHEMBL4784443 | US11306078, Example 4.012)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells at -40 mV holding potential by Q-patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetAtypical chemokine receptor 3(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555322(CHEMBL4784443 | US11306078, Example 4.012)
Affinity DataIC50: 49nMAssay Description:Tango CXCR7-bla U2OS cells are detached from culture dishes with 0.05% trypsin-EDTA and collected in growing medium (McCoy's 5A 90% (v/v), dialyz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2022
Entry Details
Go to US Patent