BDBM50557246 CHEMBL4761365

SMILES CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(Cl)cc2)[C@H](C)C1

InChI Key InChIKey=ZAVSMABHFLBCSH-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50557246   

TargetTyrosine-protein kinase JAK1(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50557246(CHEMBL4761365)
Affinity DataIC50: 0.199nMAssay Description:Inhibition of recombinant JAK1 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr followed by anti-pSTAT1 antibody addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50557246(CHEMBL4761365)
Affinity DataIC50: 0.199nMAssay Description:Inhibition of recombinant JAK1 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr followed by anti-pSTAT1 antibody addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50557246(CHEMBL4761365)
Affinity DataIC50: 3.36nMAssay Description:Inhibition of recombinant JAK3 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr followed by anti-pSTAT1 antibody addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50557246(CHEMBL4761365)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of recombinant JAK3 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr followed by anti-pSTAT1 antibody addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50557246(CHEMBL4761365)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of recombinant JAK2 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr followed by anti-pSTAT1 antibody addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50557246(CHEMBL4761365)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of recombinant JAK2 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr followed by anti-pSTAT1 antibody addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50557246(CHEMBL4761365)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of recombinant TYK2 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr followed by anti-pSTAT1 antibody addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50557246(CHEMBL4761365)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of recombinant TYK2 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr followed by anti-pSTAT1 antibody addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50557246(CHEMBL4761365)
Affinity DataIC50: 106nMAssay Description:Inhibition of recombinant human FLT1 (783 to end residues) assessed as residual activity using KKKSPGEYVNIEF as substrate incubated for 40 mins in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50557246(CHEMBL4761365)
Affinity DataIC50: 230nMAssay Description:Inhibition of JAK1 pathway in human TF-1 cells assessed as decrease in IL6-induced STAT3 phosphorylation preincubated for 30 mins followed by IL-6 st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50557246(CHEMBL4761365)
Affinity DataIC50: 760nMAssay Description:Inhibition of JAK2 pathway in human TF-1 cells assessed as decrease in IL3-induced STAT5 phosphorylation preincubated for 1 hr followed by IL-3 stimu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed