BDBM50557483 CHEMBL4782814

SMILES [H][C@]12C[C@]([H])(C[C@H](CC1)Nc1nc(Nc3cc(C)[nH]n3)cc3ncccc13)N2CCC#N

InChI Key InChIKey=CATOAFRPSWLOCV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50557483   

TargetTyrosine-protein kinase JAK1(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557483(CHEMBL4782814)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human JAK1 assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557483(CHEMBL4782814)
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant human JAK2 assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557483(CHEMBL4782814)
Affinity DataIC50: 992nMAssay Description:Inhibition of recombinant human JAK3 assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557483(CHEMBL4782814)
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant human Tyk2 expressed in sf21 baculovirus expression system assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed