BDBM50557743 CHEMBL4744988

SMILES CNc1nc2c(cnn2cc1C1CC1)-c1ccnc(OC)c1

InChI Key InChIKey=RGHVGCXGMWBBJX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50557743   

TargetTGF-beta receptor type-2(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50557743(CHEMBL4744988)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of TGFbeta receptor 2 (unknown origin) using biotin-labelled TTLKDLIYDMTTSGSGSGLPLLVQRTIARTsubstrate in presence of [gamma33P] ATP measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetActivin receptor type-2A(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50557743(CHEMBL4744988)
Affinity DataIC50: 630nMAssay Description:Inhibition of ACVR2A (unknown origin) using biotin- labelled KTLQDLVYDLSTSGSGSGLPLFVQRTVART substrate in presence of [gamma33P] ATP measured after 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50557743(CHEMBL4744988)
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of ALK5 (unknown origin) using biotin-labelled KKKVLTQMGSPSIRCSpSVS substrate in presence of [gamma33P] ATP measured after 40 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed