BDBM50558089 CHEMBL4788780

SMILES C[C@H]1CC[C@H](CN1C(=O)C1(O)CCC1)c1nc(-c2ccc(cc2F)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12

InChI Key InChIKey=XBWHYQMGVRQMTB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50558089   

TargetTyrosine-protein kinase BTK(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50558089(CHEMBL4788780)
Affinity DataIC50: 0.520nMAssay Description:Reversible inhibition of recombinant full length BTK (unknown origin) baculovirus infected Sf9 cells using biotinylated EQEDEPEGDYFEWLE-NH2 peptide a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50558089(CHEMBL4788780)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of BTK in human PBMC assessed as reduction in cell surface CD69 expression preincubated for 1 hr followed by stimulation with goat anti-hu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed