BDBM50558111 CHEMBL4796764

SMILES Cc1ccnc(NC(=O)c2ccc(-c3nc([C@@H]4CCCN(C4)C(=O)C4(C)COC4)n4ccnc(N)c34)c(F)c2)c1

InChI Key InChIKey=YTUINWBJGLGJFD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50558111   

TargetTyrosine-protein kinase BTK(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50558111(CHEMBL4796764)
Affinity DataIC50: 1.20nMAssay Description:Reversible inhibition of recombinant full length BTK (unknown origin) baculovirus infected Sf9 cells using biotinylated EQEDEPEGDYFEWLE-NH2 peptide a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50558111(CHEMBL4796764)
Affinity DataIC50: 50nMAssay Description:Inhibition of BTK in human PBMC assessed as reduction in cell surface CD69 expression preincubated for 1 hr followed by stimulation with goat anti-hu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed