BDBM50558272 CHEMBL4744101

SMILES O\N=C(/Nc1ccc([N+]([O-])=O)c2nonc12)c1ccccc1F

InChI Key InChIKey=LHFMCJFWSFJACX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50558272   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Indian Institute of Technology Guwahati

Curated by ChEMBL
LigandPNGBDBM50558272(CHEMBL4744101)
Affinity DataIC50: 56nMAssay Description:Inhibition of recombinant human IDO1 assessed as N-formylkynurenine formation using L-tryptophan as substrate measured after 1.5 hrs by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Indian Institute of Technology Guwahati

Curated by ChEMBL
LigandPNGBDBM50558272(CHEMBL4744101)
Affinity DataIC50: 63nMAssay Description:Inhibition of recombinant human IDO1 assessed as N-formylkynurenine formation using L-tryptophan as substrate measured after 1 hr by UV-vis spectroph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Indian Institute of Technology Guwahati

Curated by ChEMBL
LigandPNGBDBM50558272(CHEMBL4744101)
Affinity DataIC50: 131nMAssay Description:Inhibition of human IDO1 in IFN-gamma-induced human MDA-MB-231 cells assessed as N-formylkynurenine formation using L-tryptophan as substrate pretrea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Indian Institute of Technology Guwahati

Curated by ChEMBL
LigandPNGBDBM50558272(CHEMBL4744101)
Affinity DataIC50: 1.10E+5nMAssay Description:Inhibition of recombinant human TDO assessed as N-formylkynurenine formation using L-tryptophan as substrate measured after 1 hrs by UV-vis spectroph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed