BDBM50559319 CHEMBL4791717

SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1c(C)c2ccc(F)cn2c(=O)c1-c1ccccc1

InChI Key InChIKey=QUHNSCKGYHQCHA-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50559319   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Lupin

Curated by ChEMBL

LigandBDBM50559319(CHEMBL4791717)Copy SMILESCopy InChI

Affinity DataIC50: 5.60nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/27/2022
Entry Details Article
Copy BDB DOIPubMed
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Lupin

Curated by ChEMBL

LigandBDBM50559319(CHEMBL4791717)Copy SMILESCopy InChI

Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of PI3Kalpha in human MDA-MB-453 cells assessed as reduction in phosphorylation of AKT at 473 measured after 1 hr by alpha screen assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/27/2022
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL