BDBM50563589 CHEMBL4744255

SMILES COc1ccc(C[C@H](NC(=O)[C@H](C)NC(=O)c2ccc(o2)-c2ccc(cc2)C(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)C(=O)Nc2cccc(c2)C(C)=O)cc1

InChI Key InChIKey=SUQBHZSJXAKKQX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50563589   

TargetProteasome subunit beta type-8(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50563589(CHEMBL4744255)
Affinity DataIC50: 25nMAssay Description:Inhibition of 20S immunoproteasome beta 5 chymotrypsin-like activity in human H226 cell using Suc-LLVY-AMC as substrate for 10 mins by fluorescence b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetProteasome subunit beta type-2(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50563589(CHEMBL4744255)
Affinity DataIC50: 133nMAssay Description:Inhibition of 20S immunoproteasome beta 2 trypsin-like activity in human H226 cell using Z-LRR-aminoluciferin as substrate for 10 mins by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50563589(CHEMBL4744255)
Affinity DataIC50: 418nMAssay Description:Inhibition of 20S immunoproteasome beta 1 caspase-like activity in human H226 cell using Z-nLPnLD-aminoluciferin as substrate for 10 mins by fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed