BDBM50565177 CHEMBL4796622

SMILES CCCCNc1nc2cc(ccc2s1)[N+]([O-])=O

InChI Key InChIKey=KGMPZRJHVILPMZ-UHFFFAOYSA-N

Data  13 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50565177   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Paris-Saclay University

Curated by ChEMBL
LigandPNGBDBM50565177(CHEMBL4796622)
Affinity DataEC50:  4.70E+3nMAssay Description:Inhibition of RIPK1 in human FADD-deficient Jurkat I 2.1 cells assessed as protection against TNFalpha-induced necroptosis measured after 24 hrs by M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Paris-Saclay University

Curated by ChEMBL
LigandPNGBDBM50565177(CHEMBL4796622)
Affinity DataIC50: 2.89E+3nMAssay Description:Inhibition of recombinant human RIPK1 kinase domain (8 to 322 residues) using myelin basic protein as substrate measured after 120 mins by [gamma-32P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Paris-Saclay University

Curated by ChEMBL
LigandPNGBDBM50565177(CHEMBL4796622)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK2/cyclin A using histone H1 as substrate by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Paris-Saclay University

Curated by ChEMBL
LigandPNGBDBM50565177(CHEMBL4796622)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CDK5/p25 expressed in bacterial expression using histone H1 as substrate by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Paris-Saclay University

Curated by ChEMBL
LigandPNGBDBM50565177(CHEMBL4796622)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CDK9/cyclin T expressed in baculovirus infected Sf9 insect cells using YSPTSPSYSPTSPSYSPTSPSKKKK as substrate by ADP-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK1(Mouse)
Paris-Saclay University

Curated by ChEMBL
LigandPNGBDBM50565177(CHEMBL4796622)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of mouse recombinant CLK1 expressed in bacterial expression system using GRSRSRSRSRSR as substrate by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Rat)
Paris-Saclay University

Curated by ChEMBL
LigandPNGBDBM50565177(CHEMBL4796622)
Affinity DataIC50: 2.21E+3nMAssay Description:Inhibition of recombinant rat DYRK1A kinase domain (1 to 499 residues) expressed in bacterial expression system using KKISGRLSPIMTEQ as substrate by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase haspin(Human)
Paris-Saclay University

Curated by ChEMBL
LigandPNGBDBM50565177(CHEMBL4796622)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human HASPIN kinase domain (470 to 798 residues) expressed in bacterial expression system using histone H3(1-21) peptide as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Paris-Saclay University

Curated by ChEMBL
LigandPNGBDBM50565177(CHEMBL4796622)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human PIM1 expressed in bacterial expression system using histone H1 as substrate by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCasein kinase I isoform epsilon(Human)
Paris-Saclay University

Curated by ChEMBL
LigandPNGBDBM50565177(CHEMBL4796622)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human CK1epsilon expressed in baculovirus infected Sf9 insect cells using RRKHAAIGSpAYSITA as substrate by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Paris-Saclay University

Curated by ChEMBL
LigandPNGBDBM50565177(CHEMBL4796622)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human JAK3 C-terminal domain (781 to 1124 residues) expressed in baculovirus infected Sf9 insect cells using GGEEEEYFELVKKK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Paris-Saclay University

Curated by ChEMBL
LigandPNGBDBM50565177(CHEMBL4796622)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human ABL1 (118 to 535 residues) expressed in baculovirus infected Sf9 insect cells using EAIYAAPFAKKK as substrate by ADP-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Paris-Saclay University

Curated by ChEMBL
LigandPNGBDBM50565177(CHEMBL4796622)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human RIPK3 expressed in baculovirus infected Sf9 insect cells using myelin basic protein as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Paris-Saclay University

Curated by ChEMBL
LigandPNGBDBM50565177(CHEMBL4796622)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human AURKB expressed in baculovirus infected Sf9 insect cells using myelin basic protein as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed