BDBM50568246 CHEMBL4854692

SMILES CC(C)(C)Nc1c(nc2ccccn12)-c1ccc(cc1)-c1noc(n1)C(F)(F)F

InChI Key InChIKey=QCKNTQLUQMEQRQ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50568246   

TargetHistone deacetylase 5(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50568246(CHEMBL4854692)
Affinity DataIC50: 812nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant full length HDAC5 expressed in baculovirus-infected Sf9 cells assessed as reduction in 7-amino-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50568246(CHEMBL4854692)
Affinity DataIC50: 2.31E+3nMAssay Description:Inhibition of C-terminal His-tagged human HDAC9 (604 to 1066 residues) expressed in baculovirus-infected Sf9 cells assessed as reduction in 7-amino-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50568246(CHEMBL4854692)
Affinity DataIC50: 3.58E+3nMAssay Description:Inhibition of N-terminal GST-tagged/C-terminal His-tagged human recombinant HDAC4 (627 to 1084 residues) expressed in baculovirus-infected Sf9 cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50568246(CHEMBL4854692)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC7 (518 to end residues) expressed in baculovirus-infected Sf9 cells assessed as reduction in 7-amino-4-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50568246(CHEMBL4854692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal FLAG/His-tagged human recombinant HDAC1 (1 to 482 residues) expressed in baculovirus-infected Sf9 cells assessed as reductio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50568246(CHEMBL4854692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal 6XHis-tagged human recombinant full length HDAC2 (1 to 488 residues) expressed in baculovirus-infected Sf9 cells assessed as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
LigandPNGBDBM50568246(CHEMBL4854692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal His-tagged human recombinant full length HDAC3 (1 to 428 residues)/N-terminal GST-tagged human recombinant NCOR2 (395 to 489...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed