BDBM50568780 (r)-pramipexole::Dexpramipexole

SMILES [H][C@]1(CCc2nc(N)sc2C1)NCCC

InChI Key InChIKey=FASDKYOPVNHBLU-UHFFFAOYSA-N

Data  3 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50568780   

TargetD(3) dopamine receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50568780(Dexpramipexole | (r)-pramipexole)
Affinity DataKi:  0.661nMAssay Description:Displacement of [3H]N-methylspiperone from human D3 receptor expressed in HEK293T cells co-expressing CRE-Luc incubated for 60 mins by microbeta scin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50568780(Dexpramipexole | (r)-pramipexole)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]N-methylspiperone from human D2L receptor expressed in HEK293T cells co-expressing CRE-Luc incubated for 60 mins by microbeta sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50568780(Dexpramipexole | (r)-pramipexole)
Affinity DataEC50:  8.51E+3nMAssay Description:Agonist activity at human histamine receptor expressed in sf9 insect cell membranes co-exprssing GsalphaS incubated for 90 mins [35S]GTPgammaS bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50568780(Dexpramipexole | (r)-pramipexole)
Affinity DataKi:  1.38E+4nMAssay Description:Displacement of [3H]UR-DE257 from human histamine H2 receptor expressed in sf9 insect cell membranes co-expressing GSalphaS incubated for 60 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50568780(Dexpramipexole | (r)-pramipexole)
Affinity DataEC50:  3.98E+4nMAssay Description:Agonist activity at human histamine H2 receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed