BDBM50568800 CHEMBL4859647

SMILES COc1cc2CC(CC3(F)CCN(Cc4ccccc4F)CC3)C(=O)c2cc1OC

InChI Key InChIKey=DCZOKUPYRTZAFN-UHFFFAOYSA-N

Data  10 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50568800   

TargetAcetylcholinesterase(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50568800(CHEMBL4859647)
Affinity DataIC50: 0.860nMAssay Description:Inhibition of rat cortex homogenate acetylcholinesterase using acetylthiocholine iodide as substrate incubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50568800(CHEMBL4859647)
Affinity DataKd:  3.5nMAssay Description:Binding affinity to CM5 sensor chip immobilized recombinant human AChE assessed as dissociation constant at 298.15 K by surface plasmon resonance ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50568800(CHEMBL4859647)
Affinity DataIC50: 3.17E+4nMAssay Description:Inhibition of rat serum BuChE using S-butyrylthiocholine iodide as substrate incubated for 8 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50568800(CHEMBL4859647)
Affinity DataIC50: 9.23E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50568800(CHEMBL4859647)
Affinity DataIC50: 4.77E+3nMAssay Description:Inhibition of CYP2C9 in human hepatocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50568800(CHEMBL4859647)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2 in human hepatocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50568800(CHEMBL4859647)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2B6 in human hepatocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50568800(CHEMBL4859647)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C8 in human hepatocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50568800(CHEMBL4859647)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C19 in human hepatocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50568800(CHEMBL4859647)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 in human hepatocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50568800(CHEMBL4859647)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 in human hepatocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed