BDBM50568928 CHEMBL4852860

SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccc(Cl)cc4)c(=O)n(C)c3n2)cc1

InChI Key InChIKey=BKKLKDBGZYFYHB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50568928   

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
University of Houston

Curated by ChEMBL
LigandPNGBDBM50568928(CHEMBL4852860)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant RIPK2 (unknown origin) using RS repeat peptide as substrate preincubated for 5 mins followed by substrate and ATP addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50568928(CHEMBL4852860)
Affinity DataIC50: 950nMAssay Description:Inhibition of human NOD2 expressed in HEK-blue cells coexpressing NFkappaB-SEAP reporter assessed as reduction in L18-MDP-induced NF-kappaB activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
University of Houston

Curated by ChEMBL
LigandPNGBDBM50568928(CHEMBL4852860)
Affinity DataIC50: 2.94E+3nMAssay Description:Inhibition of human ALK2 using casein as substrate incubated for 30 mins in presence of [gamma33P]ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed