BDBM50570328 CHEMBL4871326

SMILES [H][C@@]12CCc3cc(ccc3[C@@]1(CCN2N[C@@H]1CC[C@H](C[C@@H]1C)C(O)=O)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F

InChI Key InChIKey=MUHYHLFUAPFACM-UHFFFAOYSA-N

Data  7 IC50  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50570328   

TargetNuclear receptor ROR-gamma(Mouse)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50570328(CHEMBL4871326)
Affinity DataEC50:  11nMAssay Description:Inverse agonist activity at RORgammat in mouse Th17 cells assessed as inhibition of CD3/CD28/IL-1/IL-23-induced IL-17A production measured after 24 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50570328(CHEMBL4871326)
Affinity DataEC50:  12nMAssay Description:Inverse agonist activity at recombinant full-length human Gal4-fused RORgammat expressed in human Jurkat cells incubated for 18 hrs by steady-glo luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50570328(CHEMBL4871326)
Affinity DataEC50:  24nMAssay Description:Inverse agonist activity at RORgammat in CD3 and CD28-stimulated human whole blood assessed as suppression of IL17 preincubated for 1 hr followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50570328(CHEMBL4871326)
Affinity DataEC50: >5.00E+3nMAssay Description:Inverse agonist activity at LXRbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50570328(CHEMBL4871326)
Affinity DataEC50: >5.00E+3nMAssay Description:Inverse agonist activity at PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50570328(CHEMBL4871326)
Affinity DataEC50: >5.00E+3nMAssay Description:Inverse agonist activity at LXRalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-alpha(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50570328(CHEMBL4871326)
Affinity DataEC50: >1.00E+4nMAssay Description:Inverse agonist activity at Gal4-fused RORalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-beta(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50570328(CHEMBL4871326)
Affinity DataEC50: >1.00E+4nMAssay Description:Inverse agonist activity at Gal4-fused RORbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50570328(CHEMBL4871326)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50570328(CHEMBL4871326)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50570328(CHEMBL4871326)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50570328(CHEMBL4871326)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50570328(CHEMBL4871326)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50570328(CHEMBL4871326)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50570328(CHEMBL4871326)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG by patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed