BDBM50570559 CHEMBL4868687

SMILES COC(=O)C(=N/Nc1ccc(C)cc1)\C(=O)C(F)(F)F

InChI Key InChIKey=WBTOVOOOKUVTED-UHFFFAOYSA-N

Data  3 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50570559   

TargetLiver carboxylesterase(Pig)
Institute of Physiologically Active Compounds Russian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50570559(CHEMBL4868687)
Affinity DataIC50: 28nMAssay Description:Inhibition of porcine liver carboxylesterase using 4-NPA as substrate preincubated for 10 mins followed by substrate addition by spectrophotometric a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Institute of Physiologically Active Compounds Russian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50570559(CHEMBL4868687)
Affinity DataIC50: 2.83E+4nMAssay Description:Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetCholinesterase(Horse)
Institute of Physiologically Active Compounds Russian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50570559(CHEMBL4868687)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of equine serum BuChE using butyrylcholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
Institute of Physiologically Active Compounds Russian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50570559(CHEMBL4868687)
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant CES1 expressed in baculovirus infected BTI insect cells using 4-NPA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetCocaine esterase(Human)
Institute of Physiologically Active Compounds Russian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50570559(CHEMBL4868687)
Affinity DataIC50: 193nMAssay Description:Inhibition of human recombinant CES2 expressed in mouse NSO cells using 4-NPA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetLiver carboxylesterase(Pig)
Institute of Physiologically Active Compounds Russian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50570559(CHEMBL4868687)
Affinity DataKi:  14nMAssay Description:Competitive inhibition of porcine liver carboxylesterase by double reciprocal Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Institute of Physiologically Active Compounds Russian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50570559(CHEMBL4868687)
Affinity DataKi:  1.01E+4nMAssay Description:Competitive inhibition of human erythrocyte AChE by double reciprocal Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetCholinesterase(Horse)
Institute of Physiologically Active Compounds Russian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50570559(CHEMBL4868687)
Affinity DataKi:  2.92E+4nMAssay Description:Competitive inhibition of equine serum BuChE by double reciprocal Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed