BDBM50570944 CHEMBL4866245::US12473296, Example 187

SMILES CC(C)NC(=O)c1cc(cnc1N)-c1ccc(NC(=O)Cc2ccccc2)cc1C

InChI Key InChIKey=QXFDNMNTISNJLZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50570944   

LigandChemical structure of BindingDB Monomer ID 50570944BDBM50570944(CHEMBL4866245 | US12473296, Example 187)
Affinity DataIC50: 73nMAssay Description:Inhibition of human His-tagged PERK expressed in Escherichia coli assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50570944BDBM50570944(CHEMBL4866245 | US12473296, Example 187)
Affinity DataIC50: 75.5nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50570944BDBM50570944(CHEMBL4866245 | US12473296, Example 187)
Affinity DataIC50: 307nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed