BDBM50570951 CHEMBL4865268::US12473296, Example 41

SMILES Cc1cc(NC(=O)C(O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(c1)C(O)=O

InChI Key InChIKey=GTVXRXBVDPTLON-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50570951   

TargetInterferon-induced, double-stranded RNA-activated protein kinase [252-551]/Eukaryotic translation initiation factor 2-alpha kinase 3 [536-1116](Human)
Hibercell

US Patent

LigandBDBM50570951(CHEMBL4865268 | US12473296, Example 41)Copy SMILESCopy InChI

Affinity DataIC50: 176nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/8/2026
Entry Details
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TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Hibercell

Curated by ChEMBL

LigandBDBM50570951(CHEMBL4865268 | US12473296, Example 41)Copy SMILESCopy InChI

Affinity DataIC50: 241nMAssay Description:Inhibition of human His-tagged PERK expressed in Escherichia coli assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/20/2022
Entry Details Article
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