BDBM50570954 CHEMBL4876223

SMILES CN(C)C(=O)c1cc(cnc1N)-c1ccc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)cc1C

InChI Key InChIKey=FQUUOXSYZPUEQY-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50570954   

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Hibercell

Curated by ChEMBL

LigandBDBM50570954(CHEMBL4876223)Copy SMILESCopy InChI

Affinity DataIC50: 599nMAssay Description:Inhibition of human His-tagged PERK expressed in Escherichia coli assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/20/2022
Entry Details Article
Copy Entry DOIPubMed
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TargetEukaryotic translation initiation factor 2 subunit 1(Human)
Hibercell

Curated by ChEMBL

LigandBDBM50570954(CHEMBL4876223)Copy SMILESCopy InChI

Affinity DataIC50: 2.22E+3nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/20/2022
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL