BDBM50570957 CHEMBL4876496

SMILES Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(c1)C(=O)NC(C)(C)C

InChI Key InChIKey=XFMJNFJUBNDIMV-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50570957   

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Hibercell

Curated by ChEMBL

LigandBDBM50570957(CHEMBL4876496)Copy SMILESCopy InChI

Affinity DataIC50: 33nMAssay Description:Inhibition of human His-tagged PERK expressed in Escherichia coli assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/20/2022
Entry Details Article
Copy BDB DOIPubMed
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TargetEukaryotic translation initiation factor 2 subunit 1(Human)
Hibercell

Curated by ChEMBL

LigandBDBM50570957(CHEMBL4876496)Copy SMILESCopy InChI

Affinity DataIC50: 114nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/20/2022
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL