BDBM50571012 CHEMBL4867696

SMILES CN1CCC(CC(=O)Nc2cc(Oc3ccc(NC(=O)c4cn(C5CCCC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)ccn2)CC1

InChI Key InChIKey=MBJBZECMDXNZSX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50571012   

TargetTyrosine-protein kinase receptor UFO(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50571012(CHEMBL4867696)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50571012(CHEMBL4867696)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of recombinant human Axl expressed in mouse BaF3 cells assessed as reduction in cell viability incubated for 2 days by cell titer glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50571012(CHEMBL4867696)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human Mer expressed in mouse BaF3 cells assessed as reduction in cell viability incubated for 2 days by cell titer glo assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50571012(CHEMBL4867696)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant human GST-tagged Mer using biotinylated peptide as substrate incubated for 1 hr by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed