BDBM50574409 CHEMBL4873534

SMILES Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCn3cc(COCCOc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)nn3)cc2)c2ccc(O)cc12

InChI Key InChIKey=FFVRYCZYVQRFPI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50574409   

TargetEstrogen receptor(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM50574409(CHEMBL4873534)
Affinity DataIC50: 1.60nMAssay Description:Binding affinity to recombinant His-tagged ERalpha LBD (307 to 554 residue) (unknown origin) expressed in Escherichia coli preincubated for 15 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM50574409(CHEMBL4873534)
Affinity DataIC50: 2.10nMAssay Description:Binding affinity to ERalpha S463P mutant (unknown origin) expressed in Escherichia coli preincubated for 15 mins followed by ligand addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM50574409(CHEMBL4873534)
Affinity DataIC50: 3.20nMAssay Description:Binding affinity to ERalpha Y537S mutant (unknown origin) expressed in Escherichia coli preincubated for 15 mins followed by ligand addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
X-Chem

Curated by ChEMBL
LigandPNGBDBM50574409(CHEMBL4873534)
Affinity DataIC50: 4.70nMAssay Description:Binding affinity to ERalpha D538G mutant (unknown origin) expressed in Escherichia coli preincubated for 15 mins followed by ligand addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed