BDBM50575223 CHEMBL4863309

SMILES CCN(C(=O)C1CC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1cnc(N2CCN(CC3CC3)CC2)c(C)c1

InChI Key InChIKey=KESSZZBYKMGKKM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50575223   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50575223(CHEMBL4863309)
Affinity DataIC50: 12nMAssay Description:Inhibition of EZH2 (unknown origin) using SAM as substrate incubated for 60 mins by luminescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50575223(CHEMBL4863309)
Affinity DataIC50: 30nMAssay Description:Inhibition of EZH2 Y641F mutant (unknown origin) using SAM as substrate incubated for 60 mins by luminescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed