BDBM50575224 CHEMBL4872040

SMILES CCN(C(=O)C1CC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1cnc(cc1C)N1CCN(CC2CC2)CC1

InChI Key InChIKey=CWOPVAGVHOYUSO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50575224   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50575224(CHEMBL4872040)
Affinity DataIC50: 17nMAssay Description:Inhibition of EZH2 (unknown origin) using SAM as substrate incubated for 60 mins by luminescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50575224(CHEMBL4872040)
Affinity DataIC50: 40nMAssay Description:Inhibition of EZH2 Y641F mutant (unknown origin) using SAM as substrate incubated for 60 mins by luminescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed