BDBM50575236 CHEMBL4874673

SMILES Cc1c(nnn1-c1ccccn1)C(=O)Nc1ccc2COB(O)c2c1

InChI Key InChIKey=NZLNNIUTJOYBMK-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50575236   

TargetCytochrome P450 2D6(Human)
Drugs For Neglected Diseases Initiative (Dndi)

Curated by ChEMBL
LigandPNGBDBM50575236(CHEMBL4874673)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 in pooled human liver microsomes using dextromethorphan as substrate preincubated for 30 mins in presence of NADPH followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Drugs For Neglected Diseases Initiative (Dndi)

Curated by ChEMBL
LigandPNGBDBM50575236(CHEMBL4874673)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 in pooled human liver microsomes using midazolam or testosterone as substrate preincubated for 30 mins in presence of NADPH foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Drugs For Neglected Diseases Initiative (Dndi)

Curated by ChEMBL
LigandPNGBDBM50575236(CHEMBL4874673)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP1A2 in pooled human liver microsomes using phenacetin as substrate preincubated for 30 mins in presence of NADPH followed by substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Drugs For Neglected Diseases Initiative (Dndi)

Curated by ChEMBL
LigandPNGBDBM50575236(CHEMBL4874673)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 in pooled human liver microsomes using diclofenac as substrate preincubated for 30 mins in presence of NADPH followed by substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Drugs For Neglected Diseases Initiative (Dndi)

Curated by ChEMBL
LigandPNGBDBM50575236(CHEMBL4874673)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C19 in pooled human liver microsomes using (S)-(+)-mephenytoin as substrate preincubated for 30 mins in presence of NADPH followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed