BDBM50575429 CHEMBL4859314

SMILES COc1ccc(OC)c(c1)-n1nnc(c1C)S(=O)(=O)c1ccc(cc1)C(C)(C)OC

InChI Key InChIKey=LJPCPXYDKHSNBM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50575429   

TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50575429(CHEMBL4859314)
Affinity DataIC50: 400nMAssay Description:Inverse agonist activity at human PXR expressed in HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter incubated for 24 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50575429(CHEMBL4859314)
Affinity DataIC50: 2.30E+3nMAssay Description:Antagonist activity at human PXR expressed in HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter incubated for 24 hrs in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50575429(CHEMBL4859314)
Affinity DataIC50: 3.70E+3nMAssay Description:Displacement of BODIPY FL vindoline from GST-tagged human PXR LBD incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed