BDBM50577241 CHEMBL4848035::US20240239774, Example 2

SMILES Cc1c(Cc2cccs2)c(nn1C)-c1cc(Cl)nc(N)n1

InChI Key InChIKey=JQJMCWHQDZMPPU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50577241   

TargetAdenylate cyclase type 10(Human)
Cornell University

US Patent
LigandPNGBDBM50577241(CHEMBL4848035 | US20240239774, Example 2)
Affinity DataIC50: 50nMAssay Description:Assays for sAC activity using purified protein were performed in 100 ul reactions containing 4 mM MgCl2, 2 mM CaCl2, 1 mM ATP, 40 mM NaHCO3, 50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2024
Entry Details
US Patent

TargetAdenylate cyclase type 10(Human)
Cornell University

US Patent
LigandPNGBDBM50577241(CHEMBL4848035 | US20240239774, Example 2)
Affinity DataIC50: 74nMAssay Description:Inhibition of human soluble adenylyl cyclase assessed as reduction in cAMP levels in the presence of alpha-32p labeled ATP by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetAdenylate cyclase type 10(Human)
Cornell University

US Patent
LigandPNGBDBM50577241(CHEMBL4848035 | US20240239774, Example 2)
Affinity DataIC50: 102nMAssay Description:Inhibition of human soluble adenylyl cyclase transfected (4-4 clones)in human HEK293 cells assessed as reduction in cAMP levels preincubated for 5 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed