BDBM50577791 CHEMBL4849505

SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2c1CN(Cc1cc(F)cc(F)c1)C2(C)C

InChI Key InChIKey=XHKNPVMZBCKSLF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50577791   

TargetBDNF/NT-3 growth factors receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50577791(CHEMBL4849505)
Affinity DataIC50: 11nMAssay Description:Inhibition of human intracellular domain of TRKB expressed in Sf9 cells incubated for 1 hr by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50577791(CHEMBL4849505)
Affinity DataIC50: 11nMAssay Description:Inhibition of N-terminal GST-tagged human TRKC (456 to 825 residues) expressed in Sf21 using TK as substrate in presence of ATP measured after 40 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50577791(CHEMBL4849505)
Affinity DataIC50: 17nMAssay Description:Inhibition of N-terminal GST-tagged human TRKA (436 to 790 residues) expressed in baculovirus infected Sf21 cells using TK as substrate in presence o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50577791(CHEMBL4849505)
Affinity DataIC50: 28nMAssay Description:Inhibition of human intracellular domain of TRKA expressed in Sf9 cells incubated for 1 hr by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50577791(CHEMBL4849505)
Affinity DataIC50: 28nMAssay Description:Inhibition of N-terminal GST-tagged human TRKB (456 to 822 residues) expressed in baculovirus infected Sf21 cells using TK as substrate in presence o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed