BDBM50578193 CHEMBL4863580

SMILES CNc1cc(Oc2ccc(NC(=O)Nc3cccc(c3)C(F)(F)F)cc2)ncn1

InChI Key InChIKey=YUOIOAHDJBTFGF-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50578193   

TargetSerine/threonine-protein kinase TNNI3K(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50578193(CHEMBL4863580)
Affinity DataIC50: 20nMAssay Description:Inhibition of human myc-TNNI3K expressed in HEK-MSR2 cells assessed as reduction in TNNI3K autophosphorylation preincubated for 30 mins followed by p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50578193(CHEMBL4863580)
Affinity DataIC50: 25nMAssay Description:Inhibition of GST-6His tagged VEGFR2 (unknown origin) using biotin-aminohexyl-EEEEYFELVAKKKK-NH2 peptide substrate incubated for 90 mins by HTRF assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TNNI3K(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50578193(CHEMBL4863580)
Affinity DataIC50: 40nMAssay Description:Inhibition of TNNI3K (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50578193(CHEMBL4863580)
Affinity DataIC50: 500nMAssay Description:Inhibition of B-Raf (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50578193(CHEMBL4863580)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed