BDBM50578354 CHEMBL4847106

SMILES C[C@@H]1CC[C@H](C[C@H]1O)Nc1nc(NC(C)(C)C)ncc1C(N)=O

InChI Key InChIKey=QBBRJRLJWXRSHQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50578354   

TargetMitogen-activated protein kinase 8(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50578354(CHEMBL4847106)
Affinity DataIC50: 11nMAssay Description:Inhibition of JNK1 (unknown origin) assessed as reduction in phosphorylated ULight-labeled 4EBP1 peptide measured after 1 hr by time-resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50578354(CHEMBL4847106)
Affinity DataIC50: 31nMAssay Description:Inhibition of JNK2 (unknown origin) assessed as reduction in phosphorylated ULight-labeled 4EBP1 peptide measured after 1 hr by time-resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Mouse)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50578354(CHEMBL4847106)
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of c-Jun phosphorylation in LPS-stimulated JNK1-/- mouse embryonic fibroblast incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Mouse)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50578354(CHEMBL4847106)
Affinity DataIC50: 500nMAssay Description:Inhibition of c-Jun phosphorylation in LPS-stimulated JNK2-/- mouse embryonic fibroblast incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50578354(CHEMBL4847106)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of human adenosine A3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50578354(CHEMBL4847106)
Affinity DataIC50: 24nMAssay Description:Inhibition of N-terminal GST-tagged recombinant full length human JNK1 expressed in baculovirus infected Sf9 insect cells using IPTTPITTTYFFFKKK as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed