BDBM50579558 CHEMBL4860716

SMILES COc1nn(C)cc1C(=O)Nc1cccc(n1)-c1nncn1C1CC(F)(F)C1

InChI Key InChIKey=VALHFEBMDQQHJF-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50579558   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Biogen

Curated by ChEMBL

LigandBDBM50579558(CHEMBL4860716)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:Inhibition of ASK1 (unknown origin) using myelin basic protein as substrate preincubated for 20 mins followed by 33P-ATP addition and measured after ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/25/2022
Entry Details Article
Copy BDB DOIPubMed
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Biogen

Curated by ChEMBL

LigandBDBM50579558(CHEMBL4860716)Copy SMILESCopy InChI

Affinity DataIC50: 316nMAssay Description:Inhibition of full-length human ASK1 expressed in HEK293T cells assessed as reduction in autophosphorylation of ASK1 at T383 residue incubated for 1 ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/25/2022
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL