BDBM50579721 CHEMBL4798892

SMILES COc1cc(ccc1NC(=O)c1cccc(n1)-c1ccn[nH]1)N1CCC(CC1)OCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)(C)C

InChI Key InChIKey=PWCLOPMRUGHLET-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50579721   

TargetInterleukin-1 receptor-associated kinase 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579721(CHEMBL4798892)
Affinity DataIC50: 60nMAssay Description:Inhibition of truncated human N-terminal GST-fusion tagged IRAK1 (194 to 712 residues) expressed in baculovirus expression system using FAM-labelled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579721(CHEMBL4798892)
Affinity DataIC50: 260nMAssay Description:Inhibition of full length human N-terminal GST-fusion tagged IRAK4 expressed in baculovirus expression system using FAM-labelled peptide as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579721(CHEMBL4798892)
Affinity DataIC50: 1.40E+3nMAssay Description:Displacement of 5-FAM-labelled DEALA-HypYIPMDDDFQLRSF peptide from VHL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed