BDBM50579962 CHEMBL5089832::US11926614, Example 124

SMILES CCOc1ccc(nc1)-c1nnc([C@H]2C[C@@H](C2)NC(=O)c2ccnc3cccnc23)n1-c1ccccn1

InChI Key InChIKey=KPULDGYAEIJQPF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50579962   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Symeres

Curated by ChEMBL
LigandPNGBDBM50579962(CHEMBL5089832 | US11926614, Example 124)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of recombinant human TNKS2 (873 to 1162 residues) incubated for 20 hrs in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Symeres

Curated by ChEMBL
LigandPNGBDBM50579962(CHEMBL5089832 | US11926614, Example 124)
Affinity DataIC50: 5.80nMAssay Description:Biochemical IC50 values for the following compounds were determined in accordance with the following protocol (see also Anumala et al., Discovery of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2024
Entry Details
Go to US Patent