BDBM50579980 CHEMBL5077466::US11926614, Example 186

SMILES FC(F)Oc1ccc(nc1)-c1nnc([C@H]2C[C@@H](C2)NC(=O)c2cc(F)cc3nccnc23)n1-c1ccccc1F

InChI Key InChIKey=TXFIJDSECDZRLH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50579980   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Symeres

Curated by ChEMBL
LigandPNGBDBM50579980(CHEMBL5077466 | US11926614, Example 186)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of recombinant human TNKS2 (873 to 1162 residues) incubated for 20 hrs in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Symeres

Curated by ChEMBL
LigandPNGBDBM50579980(CHEMBL5077466 | US11926614, Example 186)
Affinity DataIC50: 2.40nMAssay Description:Biochemical IC50 values for the following compounds were determined in accordance with the following protocol (see also Anumala et al., Discovery of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2024
Entry Details
Go to US Patent