BDBM50580103 CHEMBL5082149

SMILES COc1cc(CC(=O)N2C[C@H](Cc3ccccc3)NC(=O)CN(C[C@H](Cc3ccccc3)NC(=O)CN(C[C@H](CCCCN)NC(=O)c3ccc(CSCCC(=O)N(CC(N)=O)C(=O)[C@H](Cc4ccccc4)NC(=O)C2)cc3)C(=O)CCC2CCCCC2)C(=O)CCc2ccccc2)cc(OC)c1

InChI Key InChIKey=LTYLQIADCJWBNS-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50580103   

TargetEpidermal growth factor receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50580103(CHEMBL5082149)
Affinity DataKd:  430nMAssay Description:Binding affinity to EGFR (unknown origin) assessed as dissociation constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50580103(CHEMBL5082149)
Affinity DataIC50: 1.77E+4nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 4 hr followed by EGF stimulation by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed