BDBM50580639 CHEMBL5085751::US20240150297, Compound 18j

SMILES Cc1n[nH]c(C)c1N1CCN(CC1)c1cc(C(O)=O)c(C)cc1F

InChI Key InChIKey=BCOQZZSLRNJWFA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50580639   

TargetTransthyretin(Human)
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50580639(CHEMBL5085751 | US20240150297, Compound 18j)
Affinity DataIC50: 600nMAssay Description:Binding affinity to human plasma TTR tetramer assessed as displacement of diclofenac-coupled FITC by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetRetinol-binding protein 4(Human)
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50580639(CHEMBL5085751 | US20240150297, Compound 18j)
Affinity DataIC50: 3.00E+3nMAssay Description:Displacement of [3H]-all trans retinol from human urine biotinylated RBP4 incubated for 16 hrs measured by Scintillation Proximity AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetTransthyretin(Human)
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50580639(CHEMBL5085751 | US20240150297, Compound 18j)
Affinity DataIC50: 600nMAssay Description:Compound binding to TTR was assessed in the fluorescence polarization assay. The assay measured competitive displacement of the fluorescent probe, FI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
Go to US Patent

TargetAT-rich interactive domain-containing protein 4A(Human)
Columbia University

US Patent
LigandPNGBDBM50580639(CHEMBL5085751 | US20240150297, Compound 18j)
Affinity DataIC50: 3.00E+3nMAssay Description:In vitro binding of compounds to RBP4. Compound binding to RBP4 was assessed in the radiometric scintillation proximity (SPA) assay that was previous...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
Go to US Patent