BDBM50580779 CHEMBL5076799

SMILES Fc1cc(cc(F)c1Nc1ccnc(Nc2ccc(cc2)C#N)n1)-c1ccncc1

InChI Key InChIKey=CIIVXOPXIKFBCK-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50580779   

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50580779(CHEMBL5076799)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of recombinant wild-type HIV1 p66/p51 reverse transcriptase assessed as inhibition of [3H]dGTP incorporation using poly (rA) as templates ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50580779(CHEMBL5076799)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of human CYP2C19 using S-mephenytoin as substrate in presence of NADPH incubated for 15 to 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50580779(CHEMBL5076799)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP3A4 using testosterone as substrate in presence of NADPH incubated for 15 to 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50580779(CHEMBL5076799)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP3A4 using midazolam as substrate in presence of NADPH incubated for 15 to 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50580779(CHEMBL5076799)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP1A2 using phenacetin as substrate in presence of NADPH incubated for 15 to 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50580779(CHEMBL5076799)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP2C9 using tolbutamide as substrate in presence of NADPH incubated for 15 to 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50580779(CHEMBL5076799)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP2D6 using dextromethorphan as substrate in presence of NADPH incubated for 15 to 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed